Developmental Brain Disorder Gene Database
A curated resource for researchers & clinicians providing genotype and phenotype data from six neurodevelopmental disorders obtained from published literature.
Intellectual Disability ● Autism ● Attention Deficit Hyperactivity Disorder ● Schizophrenia ● Bipolar Disorder ● Epilepsy
Tiered Classification Methodology
- Tiers 1 and 2 are categorized as high confidence candidate genes
Tier 1Genes with three or more de novo pathogenic loss-of-function variants
Tier 2Genes with two de novo pathogenic loss-of-function variants
- Tiers 3 and 4 are categorized as emerging candidate genes
Tier 3Genes with one de novo pathogenic loss-of-function variant
Tier 4Genes with no de novo pathogenic loss-of-function variant
- AR is categorized as high confidence candidate genes
ARGenes with autosomal recessive inheritance
Tier 1: 152 genes Tier 2: 70 genes Tier 3: 108 genes Tier 4: 156 genes AR: 115 genes
Investigators are encouraged to submit cases for inclusion in the Developmental Brain Disorder Gene Database.
To submit cases for review, please contact the site curator at: firstname.lastname@example.org
Data is made freely available for research purposes. However, if this data is used in a publication,
we request you cite our article about this database in JAMA Psychiatry.
Download full LoF summary data as a CSV file (from the LoF variant table)
Download full missense summary data as a CSV file (from the missense variant table)
Download full database as a CSV file (all cases for all genes)
The Developmental Brain Disorder Gene Database is based on research presented in:
A Cross-Disorder Method to Identify Novel Candidate Genes for Developmental Brain Disorders (JAMA Psychiatry, March 2016)
Visit External Resources:SFARI gene