Developmental Brain Disorder Gene Database

A curated resource for researchers & clinicians providing genotype and phenotype data from seven neurodevelopmental disorders obtained from published literature.

Intellectual Disability ● Autism ● Attention Deficit Hyperactivity Disorder ● Schizophrenia ● Bipolar Disorder ● Epilepsy ● Cerebral Palsy

Gene
Search

LoF
Variants

Missense
Variants

Submit
Cases

Downloads

Additional
Information

Missense Variants

Last Updated: January 24, 2024 Total Cases: 4503 Total Genes: 887
Submit Cases

Investigators are encouraged to submit cases for inclusion in the Developmental Brain Disorder Gene Database.

To submit cases for review, please contact the site curator at: hshimelis@geisinger.edu

Download Data

Data is made freely available for research purposes. However, if this data is used in a publication, we request you cite our article about this database in JAMA Psychiatry.

Download full LoF summary data as a CSV file (from the LoF variant table)
Download full missense summary data as a CSV file (from the missense variant table)
Download full database as a CSV file (all cases for all genes)

Additional Information:

The Developmental Brain Disorder Gene Database is based on research presented in:
A Cross-Disorder Method to Identify Novel Candidate Genes for Developmental Brain Disorders (JAMA Psychiatry, March 2016)

Visit External Resources:
SFARI gene
Gene2phenotype
denovo-db
DDG2P Database

Autism & Developmental Medicine Institute