Developmental Brain Disorder Gene Database
LoF Variant Gene
HGNC:7879 (protein-coding gene)
CCR4-NOT transcription complex subunit 3
- Unique Cases:
- Last Updated:
- September 1, 2022
- DBD Genes Classification
- Gene Function
- Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs i... (Source: Uniprot)
- Previous symbols
- Alias symbols
- NOT3H, KIAA0691, LENG2
- Chromosomal Location
- Genomic Coordinates
- Associated Disorders
|Coe BP et. al., Neurodevelopmental disease genes implicated by de novo mutation and copy number variation morbidity., Nat Genet, 2019|
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